Why the study?
To describe subcellular and metabolic changes resulting in cardiac dysfunction in chronic diabetes and discuss therapeutic interventions.
Design
Review
Authors
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Proposed combination therapy merits prospective trials in diabetic cardiomyopathy; leaves open its additive benefit beyond neurohormonal blockade alone.
Oxidative stress plays a critical role in subcellular remodeling and metabolic abnormalities in diabetic cardiomyopathy, suggesting that combining metabolic agents or antioxidants with insulin may be an effective preventive strategy.
Dhalla et al. (2020) studied this question.
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