Cardiac Toxicity 4 to 20 Years After Completing Anthracycline Therapy

201 long-term survivors of pediatric malignancies who received chemotherapy including anthracyclines (total dose 200 to 1275 mg/m2, median 450 mg/m2), including 51 patients who had mediastinal radiotherapy.

Anthracycline therapy (median dose 450 mg/m2)

Overall incidence and severity of abnormal systolic cardiac function evaluated by echocardiogramsurrogate