Why the study?
Is the site of coronary plaque rupture or erosion characterized by an inflammatory process in patients who died of acute myocardial infarction?
Population
20 patients who died of acute myocardial infarction
Comparison
Histological and immunohistochemical analysis of… vs Adjacent cap tissue
Design
Case_series
Authors
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Active inflammation at rupture sites may contribute to plaque instability in fatal MI; hypothesis-generating for anti-inflammatory interventions in ACS.
Is the site of coronary plaque rupture or erosion characterized by an inflammatory process in patients who died of acute myocardial infarction?
The immediate site of coronary plaque rupture or erosion is consistently marked by an active inflammatory process involving macrophages and T cells, suggesting inflammation plays a key role in destabilizing the fibrous cap.
Wal et al. (1994) studied this question.
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