November 10, 2009The American Journal of Gastroenterology
Proton Pump Inhibitor and Clopidogrel Interaction: Fact or Fiction?
Why the study?
Does concomitant use of proton pump inhibitors reduce the efficacy of clopidogrel and increase cardiovascular events in patients on dual antiplatelet therapy?
Population
Patients prescribed clopidogrel plus aspirin
Comparison
Proton pump inhibitors (specifically omeprazole) vs Placebo or no proton pump inhibitor
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
No support for avoiding PPIs with clopidogrel; leaves open reconciliation with conflicting observational data.
Structured PICO
Does concomitant use of proton pump inhibitors reduce the efficacy of clopidogrel and increase cardiovascular events in patients on dual antiplatelet therapy?
P
Population
Patients prescribed clopidogrel plus aspirin
I
Intervention
Proton pump inhibitors (specifically omeprazole)
C
Comparator
Placebo or no proton pump inhibitor
O
Outcome
Cardiovascular eventshard clinical
Despite observational data and FDA warnings, randomized trial evidence does not support a causal link between PPI use and increased cardiovascular events in patients taking clopidogrel.
Cite This Study
Laine et al. (2009) studied this question.