What question did this study set out to answer?

To assess the incidence of venous thromboembolism (VTE) and its impact on survival among breast cancer patients in a large population-based study.

December 28, 2006Journal of Clinical OncologyOpen Access

Incidence of Venous Thromboembolism and the Impact on Survival in Breast Cancer Patients

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Why the study?

What is the incidence of venous thromboembolism and its impact on survival in patients with breast cancer?

Population

108,255 patients with breast cancer diagnosed between 1993 and 1999 from the California Cancer Registry

Design

Cohort

Follow-up

2 years

Authors

HCHelen K. ChewUniversity of California Davis Medical Center TWTheodore WunUniversity of California, Davis DHDanielle HarveyAlzheimer's Association

Discussion

Member takes

Implication

VTE signals poorer prognosis in breast cancer; leaves open whether targeted prophylaxis improves outcomes in randomized trials.

Key Points

To assess the incidence of venous thromboembolism (VTE) and its impact on survival among breast cancer patients in a large population-based study.
Merged California Cancer Registry with Patient Discharge Data Set
Analyzed VTE events among patients diagnosed from 1993 to 1999
Utilized multivariate models to assess risk factors and survival outcomes.
2-year cumulative VTE incidence was 1.2%, with higher rates in the first 6 months after diagnosis.
1-year incidence ratio of VTE was 4.2 times that of the general population (95% CI, 3.9 to 4.4).
VTE was associated with a 2.3 times increased risk of death within 2 years (95% CI, 2.1 to 2.6).

Structured PICO

What is the incidence of venous thromboembolism and its impact on survival in patients with breast cancer?

Population

108,255 patients with breast cancer diagnosed between 1993 and 1999 from the California Cancer Registry

Outcome

Incidence of venous thromboembolism (VTE) and 2-year survivalhard clinical

VTE occurs in approximately 1.2% of breast cancer patients within 2 years of diagnosis and is a strong predictor of decreased survival, especially in early-stage disease.

Cite This Study

Chew et al. (2006) studied this question.

synapsesocial.com/papers/69ffcbae7e61d2a3f0c230de https://doi.org/10.1200/jco.2006.07.4393

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Incidence of Venous Thromboembolism and the Impact on Survival in Breast Cancer Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Incidence of Venous Thromboembolism and the Impact on Survival in Breast Cancer Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider