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OBJECTIVE: FDG-PET) to detect longitudinal changes in frontotemporal dementia (FTD). METHODS: FDG-PET scans (total scans/visit = 270) as part of the Frontotemporal Lobar Degeneration Neuroimaging Initiative study. Linear mixed-effects models were carried out voxel-wise and in regions of interest to identify areas showing decreased volume or metabolism over time in patients as compared to controls. RESULTS: FDG-PET compared to MRI. CONCLUSION: FDG-PET and structural MRI for tracking disease progression in FTD. Both modalities showed highly overlapping patterns of longitudinal change and comparable sample size estimates to detect longitudinal changes in future clinical trials.
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Bejanin et al. (2020) studied this question.
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