Why the study?
Does acute hyperglycemia induced by a 75-gram OGTT increase platelet aggregability in human subjects?
Population
n=20 subjects undergoing 75-gram oral glucose tolerance tests (OGTT)
Comparison
75-gram oral glucose tolerance test (OGTT) vs Baseline (0 min) before glucose load
Design
Cohort
Follow-up
180 minutes
Authors
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Acute hyperglycemia was associated with increased platelet aggregability; leaves open a role for postprandial spikes in ACS pathogenesis.
Does acute hyperglycemia induced by a 75-gram OGTT increase platelet aggregability in human subjects?
Acute hyperglycemia transiently increases platelet aggregability, suggesting a potential mechanism linking postprandial glucose spikes to the onset of acute coronary syndromes.
Sakamoto et al. (2000) studied this question.