Why the study?
Does acute hyperglycemia attenuate endothelium-dependent vasodilation in healthy nondiabetic humans?
Population
20 healthy nondiabetic human subjects (two groups of 10)
Comparison
Local hyperglycemia achieved by intra-arterial… vs Baseline euglycemia; equimolar infusion of…
Design
Other
Follow-up
6 hours
Authors
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Acute hyperglycemia may impair endothelial vasodilation in healthy humans; leaves open its contribution to diabetic endothelial dysfunction.
Does acute hyperglycemia attenuate endothelium-dependent vasodilation in healthy nondiabetic humans?
Acute hyperglycemia directly impairs endothelium-dependent vasodilation in healthy humans in vivo, suggesting elevated glucose contributes to endothelial dysfunction in diabetes.
Williams et al. (1998) studied this question.
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