Why the study?
Does systemic ADMA infusion alter cardiovascular and renal hemodynamics in healthy subjects?
Population
Healthy subjects
Comparison
Systemic infusion of asymmetrical… vs Baseline (before infusion)
Design
Other
Follow-up
Short-term (during and shortly after infusion)
Authors
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ADMA acutely impairs hemodynamics in healthy subjects; confirms causal effects and extends mechanistic research to disease states.
Does systemic ADMA infusion alter cardiovascular and renal hemodynamics in healthy subjects?
Systemic ADMA infusion in healthy humans causes a short-term decrease in cardiac output and renal plasma flow, while increasing systemic vascular resistance and blood pressure.
Kielstein et al. (2003) studied this question.
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