What question did this study set out to answer?

Review the signaling pathways, transcriptional cascades, and epigenetic factors regulating Schwann cell reprogramming and repair activity following peripheral nerve damage.

April 10, 2020Cellular and Molecular Life SciencesOpen Access

Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury

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Authors

GNGianluigi NoceraLund University CJClaire JacobJohannes Gutenberg University Mainz

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Implication

Narrative review uncovers molecular mechanisms driving Schwann cell reprogramming during peripheral nerve repair, highlighting therapeutic targets for nerve regeneration.

Key Points

Review the signaling pathways, transcriptional cascades, and epigenetic factors regulating Schwann cell reprogramming and repair activity following peripheral nerve damage.
Synthesized current molecular and cellular evidence detailing the phenotypic transition of Schwann cells after nerve trauma.
Evaluated regulatory networks coordinating demyelination, myelin clearance, axon guidance, and subsequent remyelination.
Schwann cells rapidly exit their differentiated state following injury, repressing myelination genes and converting into a repair phenotype.
Reprogrammed Schwann cells reactivate immature markers and novel genes that maintain neuronal viability, clear debris, guide regenerating axons, and re-establish the myelin sheath.

Cite This Study

Nocera et al. (2020) studied this question.

synapsesocial.com/papers/69ffce642ff633f36577b1c1 https://doi.org/10.1007/s00018-020-03516-9

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Implication

Narrative review uncovers molecular mechanisms driving Schwann cell reprogramming during peripheral nerve repair, highlighting therapeutic targets for nerve regeneration.

Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury

Discussion

Member takes

Implication

Key Points

Cite This Study

Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury

Discussion

Member takes

Implication

Key Points

Cite This Study

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