What question did this study set out to answer?

To evaluate the impact of obesity on breast cancer recurrence, distant metastasis, and mortality in relation to adjuvant treatment.

November 30, 2010Journal of Clinical OncologyOpen Access

Effect of Obesity on Prognosis After Early-Stage Breast Cancer

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To evaluate the impact of obesity on breast cancer recurrence, distant metastasis, and mortality in relation to adjuvant treatment.
Analyzed 18,967 women with early-stage breast cancer and baseline body mass index (BMI) data from a nationwide cohort of 53,816 patients in Denmark treated between 1977 and 2006.
Followed patients for first recurrence events up to 10 years and overall mortality up to 30 years.
Evaluated recurrence and death risk across BMI categories using univariate analyses and multivariable Cox proportional hazards regression models adjusted for prognostic factors and adjuvant therapies.
Patients with a BMI ≥ 30 kg/m² had more advanced disease at diagnosis compared to those with a BMI < 25 kg/m² (P < .001).
After adjusting for disease characteristics, patients with BMI ≥ 30 kg/m² had a 46% increased risk of distant metastases at 10 years and a 38% increased risk of breast cancer-related death at 30 years compared to those with BMI < 25 kg/m².
BMI did not influence locoregional recurrence, but both chemotherapy and endocrine therapy appeared less effective beyond 10 years in patients with BMI > 30 kg/m².

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Implication

Cohort study reveals increased metastatic recurrence and mortality in early-stage breast cancer patients with obesity, indicating diminished long-term adjuvant therapy efficacy.

Cite This Study

Ewertz et al. (2010) studied this question.

synapsesocial.com/papers/69ffd4666be84a7ac8855744 https://doi.org/10.1200/jco.2010.29.7614

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Implication

Cohort study reveals increased metastatic recurrence and mortality in early-stage breast cancer patients with obesity, indicating diminished long-term adjuvant therapy efficacy.

Effect of Obesity on Prognosis After Early-Stage Breast Cancer

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Discussion

Implication

Cite This Study

Effect of Obesity on Prognosis After Early-Stage Breast Cancer

Key Points

Discussion

Implication

Cite This Study

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