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Review the differential diagnosis, molecular genetic causes, clinical implications, and management strategies for children born small for gestational age.

July 4, 2018Endocrine ReviewsOpen Access

Children Born Small for Gestational Age: Differential Diagnosis, Molecular Genetic Evaluation, and Implications

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Review the differential diagnosis, molecular genetic causes, clinical implications, and management strategies for children born small for gestational age.
Synthesized clinical evidence on the multifactorial causes of small for gestational age (SGA), spanning maternal, placental, and fetal epigenetic or genetic abnormalities.
Evaluated neonatal complications, spontaneous catch-up growth trajectories, and therapeutic outcomes associated with growth hormone and combined pubertal suppression therapies.
Approximately 10% of children born SGA fail to achieve spontaneous catch-up growth by 2 years of age.
Growth hormone treatment increases adult height in short children born SGA by an average of 1.25 standard deviation scores without conferring additional cardiometabolic or neurodevelopmental risk.

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Implication

Clinical review demonstrates growth hormone efficacy and long-term health risks in children born small for gestational age, highlighting the value of targeted diagnosis and early intervention.

Cite This Study

Finken et al. (2018) studied this question.

synapsesocial.com/papers/69ffd74de92f4a033c85368f https://doi.org/10.1210/er.2018-00083

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Implication

Clinical review demonstrates growth hormone efficacy and long-term health risks in children born small for gestational age, highlighting the value of targeted diagnosis and early intervention.

Children Born Small for Gestational Age: Differential Diagnosis, Molecular Genetic Evaluation, and Implications

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Discussion

Implication

Cite This Study

Children Born Small for Gestational Age: Differential Diagnosis, Molecular Genetic Evaluation, and Implications

Key Points

Discussion

Implication

Cite This Study

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