Narrative review reveals the regulation of NOX-derived reactive oxygen species by PI3K in cancer, highlighting therapeutic opportunities for oncogenic control.
Activation of NADPH oxidases (NOX) and the ensuing formation of reactive oxygen species (ROS) is a vital aspect of antimicrobial defense but may also promote tumorigenesis. Enhanced NOX activity has been associated with aberrant activation of oncogenic cascades such as the phosphoinositide 3-kinase (PI3K) signaling pathway, which is upregulated in several malignancies. In this review, we examine the role of PI3K on the regulation of NOX-induced ROS formation in cancer.
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Akhiani et al. (2022) studied this question.
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