What question did this study set out to answer?

To review the structural and functional properties of Mitofusin 2 and characterize its involvement in cellular pathways and human disease pathogenesis.

February 28, 2018Cell Death and DiseaseOpen Access

Mitofusin 2: from functions to disease

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Authors

RFRiccardo FiladiUniversity of Padua DPDiana PendinUniversity of Padua PPPaola PizzoUniversity of Padua

Discussion

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Overview

Narrative review uncovers the multifunctional roles of Mitofusin 2 across cellular pathways, highlighting its mechanistic contribution to neurodegenerative, metabolic, and cardiac diseases.

Key Points

To review the structural and functional properties of Mitofusin 2 and characterize its involvement in cellular pathways and human disease pathogenesis.
Narrative synthesis of structural and biochemical literature evaluating Mitofusin 2 activity in mitochondrial physiology.
Comprehensive examination of cellular pathways involving mitochondrial fusion, organellar tethering, motility, and mitophagy.
Mitofusin 2 regulates essential mitochondrial operations, including fusion, intracellular transport, organelle turnover, and physical tethering to the endoplasmic reticulum.
Perturbations in Mitofusin 2 function are qualitatively linked to the molecular pathogenesis of neurodegenerative conditions, metabolic disorders, cardiomyopathies, and cancer.

Cite This Study

Filadi et al. (2018) studied this question.

synapsesocial.com/papers/69ffd8a1da5c1eb07f2d8c40 https://doi.org/10.1038/s41419-017-0023-6

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February 28, 2018Cell Death and DiseaseOpen Access

Mitofusin 2: from functions to disease

View Full Paper

Ask AI

Bookmark

Authors

RFRiccardo FiladiUniversity of Padua DPDiana PendinUniversity of Padua PPPaola PizzoUniversity of Padua

Discussion

Member takes

Overview

Narrative review uncovers the multifunctional roles of Mitofusin 2 across cellular pathways, highlighting its mechanistic contribution to neurodegenerative, metabolic, and cardiac diseases.

Key Points

To review the structural and functional properties of Mitofusin 2 and characterize its involvement in cellular pathways and human disease pathogenesis.
Narrative synthesis of structural and biochemical literature evaluating Mitofusin 2 activity in mitochondrial physiology.
Comprehensive examination of cellular pathways involving mitochondrial fusion, organellar tethering, motility, and mitophagy.
Mitofusin 2 regulates essential mitochondrial operations, including fusion, intracellular transport, organelle turnover, and physical tethering to the endoplasmic reticulum.
Perturbations in Mitofusin 2 function are qualitatively linked to the molecular pathogenesis of neurodegenerative conditions, metabolic disorders, cardiomyopathies, and cancer.

Cite This Study

Filadi et al. (2018) studied this question.

synapsesocial.com/papers/69ffd8a1da5c1eb07f2d8c40 https://doi.org/10.1038/s41419-017-0023-6

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