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September 1, 2003The Journal of Experimental MedicineOpen Access

Inhibition of Respiration by Nitric Oxide Induces aMycobacterium tuberculosisDormancy Program

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Authors

MVMartin I. VoskuilDSDirk SchnappingerKVKevin Visconti

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Overview

Experimental study demonstrates that nitric oxide inhibits respiration and activates a dormancy regulon in Mycobacterium tuberculosis, suggesting a mechanism for bacterial persistence in latent...

Key Points

  • To determine how host-derived nitric oxide and oxygen availability regulate Mycobacterium tuberculosis respiration and drive the transition into a latent dormancy state.
  • Exposed Mycobacterium tuberculosis cultures to oxygen and low, nontoxic concentrations of nitric oxide to analyze changes in bacterial growth and respiration.
  • Profiled the competitive modulation of bacterial gene expression and evaluated signaling mediated by respiratory heme-containing enzymes.
  • Nitric oxide and oxygen competitively regulated a 48-gene regulon that is expressed in vivo and prepares bacilli for extended in vitro dormancy.
  • Low, nontoxic nitric oxide concentrations reversibly inhibited aerobic respiration and bacterial replication through heme-dependent sensing mechanisms.

Cite This Study

Voskuil et al. (2003) studied this question.

synapsesocial.com/papers/69ffda8f7ac91c5d2a2d63b7https://doi.org/10.1084/jem.20030205
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