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February 22, 2010Journal of Clinical OncologyOpen Access

Prognostic Significance of Focal Lesions in Whole-Body Magnetic Resonance Imaging in Patients With Asymptomatic Multiple Myeloma

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Authors

JHJens HillengaßRoswell Park Comprehensive Cancer CenterKFKerstin FechtnerGerman Cancer Research CenterMWMarc‐André WeberUniversity of Rostock

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Overview

Cohort study reveals that focal lesions on whole-body MRI strongly predict progression in asymptomatic multiple myeloma, supporting its use for risk stratification.

Key Points

  • To assess the prognostic value of focal lesions detected by whole-body magnetic resonance imaging for disease progression in patients with asymptomatic multiple myeloma.
  • Performed whole-body magnetic resonance imaging (wb-MRI) on 149 patients diagnosed with asymptomatic multiple myeloma.
  • Evaluated the presence, absence, and total count of focal lesions, alongside marrow patterns and biomarker levels, as predictors of progression to symptomatic disease.
  • Focal lesions were identified in 28% of patients at baseline.
  • The presence of focal lesions and having more than one lesion served as the strongest independent adverse predictors for progression into symptomatic multiple myeloma (P < .001 in multivariate analysis).
  • Diffuse infiltration on MRI, monoclonal protein ≥ 40 g/L, and bone marrow plasma cell infiltration ≥ 20% were additional adverse prognostic factors for progression-free survival in univariate analysis.

Cite This Study

Hillengaß et al. (2010) studied this question.

synapsesocial.com/papers/69ffe314b124fe581985aaaahttps://doi.org/10.1200/jco.2009.25.5356
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