Total Thrombus‐formation Analysis System Predicts Periprocedural Bleeding Events in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention

Figures

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  Figure 1. Patient selection process. CAG indicates coronary angiography; DAPT, dual antiplatelet therapy; PCI, percutaneous coronary intervention; SAPT, single antiplatelet therapy; TAPT, triple antiplatelet therapy.

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  Figure 2. Representative time/pressure curves of T‐TAS® of 2 patients without or with periprocedural bleeding events. A, PL chip; (B) AR chip. Thrombogenicity was evaluated by PL24‐AUC10, which represents the area under the curve (AUC) in the first 10 minutes in the platelet chip tested at flow rate of 24 μL/min, and AR10‐AUC30, which represents the AUC in the first 30 minutes in the atheroma chip tested at flow rate of 10 μL/min.

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  Figure 3. T‐TAS® and VerifyNow parameters in patients with or without periprocedural bleeding events. A, PL24‐AUC10; (B) AR10‐AUC30; and (C) PRU. In these box‐and‐whisker plots, lines within the boxes represent median values; the upper and lower lines of the boxes represent the 25th and 75th percentiles, respectively; and the upper and lower bars outside the boxes represent the maximum and minimum values, respectively. PRU indicates P2Y12 reaction units.

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  Figure 4. T‐TAS® and VerifyNow parameters in patients with and without periprocedural bleeding events who underwent PCI through the femoral approach. A, PL24‐AUC10; (B) AR10‐AUC30; and (C) PRU. In these box‐and‐whisker plots, lines within the boxes represent median values; the upper and lower lines of the boxes represent the 25th and 75th percentiles, respectively; and the upper and lower bars outside the boxes represent the maximum and minimum values, respectively. PRU indicates P2Y12 reaction units.

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  Figure 5. T‐TAS® and VerifyNow parameters in patients with and without periprocedural bleeding events who underwent PCI through the radial approach. A, PL24‐AUC10; (B) AR10‐AUC30; and (C) PRU. In these box‐and‐whisker plots, lines within the boxes represent median values; the upper and lower lines of the boxes represent the 25th and 75th percentiles, respectively; and the upper and lower bars outside the boxes represent the maximum and minimum values, respectively. PRU indicates P2Y12 reaction units.