Does type D personality increase the risk of hard endpoints in patients with cardiovascular diseases?
Type D personality is significantly associated with hard endpoints in cardiovascular disease patients, although recent methodologically sound studies suggest early studies overestimated its prognostic relevance.
BACKGROUND: Since 1995, the association of type D personality and mortality in patients with cardiovascular diseases has been increasingly investigated. PURPOSE: The aim of this meta-analysis was to integrate conflicting results and to examine possible moderators of this association. METHODS: Prospective studies assessing type D personality and hard endpoints were selected and pooled in meta-analyses. Cardiovascular diagnosis, type and quality of adjustment, and publication date were examined in moderator analyses. RESULTS: Twelve studies on patients with cardiovascular diseases (N = 5,341) were included. Pooled crude and adjusted effects demonstrated a significant association of type D personality and hard endpoints (odds ratio (OR) of 2.28 (95% CI 1.43-3.62), adjusted hazard ratio (HR) of 2.24 (95% CI 1.37-3.66)). The OR decreased over time (OR 5.02 to OR 1.54). There was no association in congestive heart failure patients. CONCLUSIONS: More recent methodologically sound studies suggest that early type D studies had overestimated the prognostic relevance.
Grande et al. (Wed,) studied this question.
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