What question did this study set out to answer?

To critically evaluate whether the oral fungus Candida albicans actively contributes to the pathogenesis of dental caries or exists merely as a benign passenger in acidic oral environments.

May 17, 2017Oral DiseasesOpen Access

Is the oral fungal pathogen Candida albicans a cariogen?

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Authors

DPDFA PereiraUniversidade Estadual Paulista (Unesp)CSCJ SeneviratneNational University of Singapore CKCristiane Yumi Koga‐ItoUniversidade Federal de Minas Gerais

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Implication

Critical review uncovers cariogenic traits of Candida albicans in the oral microbiome, suggesting a key role as a secondary pathogen in dentinal caries.

Key Points

To critically evaluate whether the oral fungus Candida albicans actively contributes to the pathogenesis of dental caries or exists merely as a benign passenger in acidic oral environments.
Reviewed molecular microbiologic evidence assessing the etiology of dental caries and the conventional hegemony of Streptococcus mutans.
Evaluated Candida virulence factors, including acidogenicity, acid tolerance, biofilm formation, dietary sugar fermentation, and collagenolytic proteinase activity.
Candida displays multiple virulent cariogenic attributes, including acid production, high acid tolerance, avid biofilm formation, and collagenolytic capability.
Current evidence supports that Candida species act as secondary contributors perpetuating the carious process rather than passive bystanders, particularly within dentinal caries.

Cite This Study

Pereira et al. (2017) studied this question.

synapsesocial.com/papers/6a001124b124fe581985bfe9 https://doi.org/10.1111/odi.12691

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Implication

Critical review uncovers cariogenic traits of Candida albicans in the oral microbiome, suggesting a key role as a secondary pathogen in dentinal caries.

Is the oral fungal pathogen Candida albicans a cariogen?

Discussion

Member takes

Implication

Key Points

Cite This Study

Is the oral fungal pathogen Candida albicans a cariogen?

Discussion

Member takes

Implication

Key Points

Cite This Study

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