Synthesis of Vinyl Sulfoxides and Subsequent Construction of C,S Contiguous Stereocenters Via Thia-Stevens Rearrangement of I III /S VI -Hybrid Ylides

Key Points

• The aim is to synthesize vinyl sulfoxides from I III/S VI-hybrid ylides and construct C,S contiguous stereocenters.
• Utilized Oppolzer's camphorsultam as a chiral auxiliary for stereoselective reactions.
• Conducted a one-pot thia-Stevens rearrangement followed by Michael addition with various nucleophiles.
• Successfully delivered products containing contiguous C,S-stereocenters through the described methods.
• The reaction exhibited a broad range of nucleophiles, expanding the scope of potential applications.