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This synthesis demonstrates the construction of C,S contiguous stereocenters in ylides using a cascade reaction with chiral auxiliaries, indicating potential in complex molecule design.
-hybrid ylides into vinyl sulfoxides. Using Oppolzer's camphorsultam as a chiral auxiliary, a one-pot stereoselective [1,2]-thia-Stevens rearrangement/Michael addition cascade was further realized with a broad range of nucleophiles, delivering products bearing contiguous C,S-stereocenters.
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Deng et al. (2026) studied this question.
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