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This narrative review examines the cellular and molecular mechanisms linking exercise to pain reduction and stress management.

May 10, 2026CellsOpen Access

Exercise-Induced Hypoalgesia: Cellular and Molecular Mechanisms Linking Pain Modulation and Stress Regulation—A Narrative Review

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This narrative review examines the cellular and molecular mechanisms linking exercise to pain reduction and stress management.
Synthesis of evidence from human and preclinical studies on exercise effects on pain and stress.
Analysis of the role of various biological systems and signaling pathways affected by exercise.
Exercise reduces pain sensitivity in both healthy individuals and chronic pain populations.
Key mechanisms include modulation of pain pathways and neuroimmune changes related to stress and pain adaptation.

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Narrative review highlights how exercise affects pain and stress through various biological mechanisms.

Gajic et al. (2026) studied this question.

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