Demonstrates high yields and enantioselectivities in copper-catalyzed propargylation of pyrazoles, suggesting efficient synthetic methods.
-selective propargylation of 5-aminopyrazoles, and the target products were obtained in very high yields (up to 99%) and enantioselectivities (up to 97:3 er). Additionally, a scale-up reaction and postsynthetic modifications of the products have been presented.
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Pavalakodi et al. (2026) studied this question.
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