Pd(II)-Catalyzed Oxidative Cyclization of Amino Alcohols with 1,3-Cyclohexadiene: A Route to Fused Morpholine Derivatives

Mao Ye; Xiaoya Zhuo; Xiangwen Tan; Wanqing Wu; Huanfeng Jiang

doi:10.1039/d6ob00613b

January 1, 2026Organic & Biomolecular Chemistry

Pd(II)-Catalyzed Oxidative Cyclization of Amino Alcohols with 1,3-Cyclohexadiene: A Route to Fused Morpholine Derivatives

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Key Points

The research aims to create a quick and effective method for synthesizing morpholine-fused bicyclic structures using catalytic reactions.
Developed a synthetic strategy involving Pd(II)-catalyzed oxidative cyclization.
Utilized 1,3-cyclohexadiene and amino alcohols.
Performed reactions under mild aerobic conditions.
Successfully constructed morpholine-fused bicyclic scaffolds.
Demonstrated efficiency and conciseness in synthetic route.
Achieved results under mild conditions without significant by-products.

Implication

Examines the synthesis of morpholine derivatives in amino alcohols, suggesting efficient pathways for structural development.

Abstract

We have developed an efficient and concise synthetic strategy for the rapid construction of morpholine-fused bicyclic scaffolds under mild aerobic conditions via Pd(II)-catalyzed oxidative cyclization of 1,3-cyclohexadiene with amino alcohol...

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Cite This Study

Ye et al. (2026) studied this question.

synapsesocial.com/papers/6a0020cec8f74e3340f9baa5 https://doi.org/10.1039/d6ob00613b

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Pd(II)-Catalyzed Oxidative Cyclization of Amino Alcohols with 1,3-Cyclohexadiene: A Route to Fused Morpholine Derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

Pd(II)-Catalyzed Oxidative Cyclization of Amino Alcohols with 1,3-Cyclohexadiene: A Route to Fused Morpholine Derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

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