Pd(II)-Catalyzed Oxidative Cyclization of Amino Alcohols with 1,3-Cyclohexadiene: A Route to Fused Morpholine Derivatives

Key Points

• The research aims to create a quick and effective method for synthesizing morpholine-fused bicyclic structures using catalytic reactions.
• Developed a synthetic strategy involving Pd(II)-catalyzed oxidative cyclization.
• Utilized 1,3-cyclohexadiene and amino alcohols.
• Performed reactions under mild aerobic conditions.
• Successfully constructed morpholine-fused bicyclic scaffolds.
• Demonstrated efficiency and conciseness in synthetic route.
• Achieved results under mild conditions without significant by-products.