High-recovery AAV clarification using a multiplexed spiral inertial microfluidic platform

Alexander Bevacqua; Do Hyun Park; Sheryar Khan; Qingxuan Li; Mahsa Hadidi; Jianzhu Chen; Jongyoon Han

doi:10.1039/d5lc01050k

January 1, 2026Lab on a Chip

High-recovery AAV clarification using a multiplexed spiral inertial microfluidic platform

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Key Points

This research aims to optimize the recovery and purification process of adeno-associated viruses (AAV) for gene therapies.
Utilized a multiplexed spiral inertial microfluidic platform for viral vector clarification.
Employed advanced bioprocessing techniques for high-recovery harvesting.
Achieved a significantly higher recovery rate of AAV compared to traditional methods, with a notable improvement in purification efficiency.

Implication

Demonstrates enhanced AAV purification efficiency using a novel microfluidic method.

Abstract

The clinical adoption of emerging cell and gene therapies relies on the efficient upstream bioprocessing and high-recovery harvesting of viral vectors. AAV purification from cell culture begins with the removal...

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Cite This Study

Bevacqua et al. (2026) studied this question.

synapsesocial.com/papers/6a0020eac8f74e3340f9bb59 https://doi.org/10.1039/d5lc01050k

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High-recovery AAV clarification using a multiplexed spiral inertial microfluidic platform

Key Points

Implication

Abstract

Discussion

Cite This Study

High-recovery AAV clarification using a multiplexed spiral inertial microfluidic platform

Key Points

Implication

Abstract

Discussion

Cite This Study

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