Synthesis, structure, and antimicrobial activity of a series of novel heterocyclic azo-colorants derived from α-dicarbonyl compounds

Thi Ngoc Anh Vu; Nadezhda Polyanskaya; Svetlana Bozhenkova; V. V. Khrustalev; Andrey Utenyshev; Anton Shetnev; Igor Filenko; Minh Chín Huỳnh; Anh Van Nguyen; Ol'ga Koval'chukova

doi:10.1039/d5ra10033j

January 1, 2026RSC AdvancesOpen Access

Synthesis, structure, and antimicrobial activity of a series of novel heterocyclic azo-colorants derived from α-dicarbonyl compounds

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Key Points

To synthesize and evaluate the antimicrobial activity of novel azo-hydrazones derived from α-dicarbonyl compounds.
Synthesis of six novel α-dicarbonyl-derived azo-hydrazones.
Evaluation of antibacterial activity and toxicity profiles.
Molecular docking and ADMET analyses to confirm drug-like properties.
Identified six novel compounds with broad-spectrum antibacterial efficacy.
Demonstrated low toxicity and high bioavailability in in vitro tests.
Molecular docking indicated strong binding affinities, supporting the inhibitory potential.

Abstract

Six novel α-dicarbonyl-derived azo–hydrazones were identified as potent, bioavailable antibacterial leads with low toxicity. Their broad-spectrum inhibitory potential and drug-like profiles were confirmed via molecular docking and ADMET analyses.

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Vu et al. (2026) studied this question.

synapsesocial.com/papers/6a002147c8f74e3340f9c0fc https://doi.org/10.1039/d5ra10033j

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Synthesis, structure, and antimicrobial activity of a series of novel heterocyclic azo-colorants derived from α-dicarbonyl compounds

Key Points

Abstract

Discussion

Cite This Study

Synthesis, structure, and antimicrobial activity of a series of novel heterocyclic azo-colorants derived from α-dicarbonyl compounds

Key Points

Abstract

Discussion

Cite This Study

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