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This research investigates how brain responses to sleep-related sounds in shift workers relate to insomnia severity and mood disorders.

May 10, 2026SLEEP

0776 Altered Salience Network Connectivity to Sleep-Related Sound Moderates the Insomnia–Depression Association in Rotating Shift Workers

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Randomized trial examines brain reactions to sleep sounds affecting insomnia and mood in shift workers, suggesting new treatment targets.

This research investigates how brain responses to sleep-related sounds in shift workers relate to insomnia severity and mood disorders.
Participants included 57 shift workers and 56 healthy controls, assessed through questionnaires and functional MRI.
Polysomnography and actigraphy tracked sleep patterns and rest-activity rhythms over one week.
Moderation analysis related insomnia severity to mood and brain connectivity.
Shift workers reported higher insomnia (W = 1985, p = 0.025) and depression scores (W = 1915, p = 0.043).
Increased functional connectivity between left anterior insula and supramarginal gyrus was observed in shift workers during sleep-related sound exposure (t = 4.76, p < 0.001).
Higher functional connectivity in the AI-SMG region was linked to a stronger association between depression and insomnia severity in shift workers.

Shin et al. (2026) studied this question.

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