What question did this study set out to answer?

This research aims to evaluate new chelating agents for radium-223 to enhance its clinical application in targeted alpha therapy.

May 10, 2026Inorganic Chemistry Frontiers0 citations

Chelation of radium with double-armed benzo-rigidified macrocycles for radiopharmaceutical purposes

AZAnastasia D. ZubenkoA. N. Nesmeyanov Institute of Organoelement Compounds APAnna V. PashanovaA. N. Nesmeyanov Institute of Organoelement Compounds LZLyubov Sergeevna ZamuruevaLomonosov Moscow State University

Key Points

This research aims to evaluate new chelating agents for radium-223 to enhance its clinical application in targeted alpha therapy.
Developed double-armed benzo-rigidified macrocycles for chelation.
Assessed the stability and kinetic inertness of the formed complexes with radium-223.
The new macrocycles successfully formed stable complexes with radium-223, demonstrating improved chelation characteristics.
Stability tests showed significantly higher kinetic inertness compared to existing agents.

Abstract

Radium-223 is a promising alpha-emitter for targeted alpha therapy (TAT), yet its clinical application is limited by the lack of chelating agents capable of forming stable and kinetically inert complexes...

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