Chelation of radium with double-armed benzo-rigidified macrocycles for radiopharmaceutical purposes

Anastasia D. Zubenko; Anna V. Pashanova; Lyubov Sergeevna Zamurueva; Ekaterina Matazova; Bayirta Egorova; Ekaterina Y. Chernikova; Валентина А. Карноухова; Ivan V. Fedyanin; Sofia P. Mosaleva; Yuri V. Fedotov; Olga Fedorova

doi:10.1039/d6qi00505e

January 1, 2026Inorganic Chemistry Frontiers

Chelation of radium with double-armed benzo-rigidified macrocycles for radiopharmaceutical purposes

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Key Points

This research aims to evaluate new chelating agents for radium-223 to enhance its clinical application in targeted alpha therapy.
Developed double-armed benzo-rigidified macrocycles for chelation.
Assessed the stability and kinetic inertness of the formed complexes with radium-223.
The new macrocycles successfully formed stable complexes with radium-223, demonstrating improved chelation characteristics.
Stability tests showed significantly higher kinetic inertness compared to existing agents.

Implication

Investigates chelation effectiveness of novel macrocycles for radiopharmaceutical use, indicating improved stability.

Abstract

Radium-223 is a promising alpha-emitter for targeted alpha therapy (TAT), yet its clinical application is limited by the lack of chelating agents capable of forming stable and kinetically inert complexes...

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Cite This Study

Zubenko et al. (2026) studied this question.

synapsesocial.com/papers/6a002162c8f74e3340f9c4c7 https://doi.org/10.1039/d6qi00505e

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Chelation of radium with double-armed benzo-rigidified macrocycles for radiopharmaceutical purposes

Key Points

Implication

Abstract

Discussion

Cite This Study

Chelation of radium with double-armed benzo-rigidified macrocycles for radiopharmaceutical purposes

Key Points

Implication

Abstract

Discussion

Cite This Study

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