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May 10, 2026PLoS ONEOpen Access

Astragaloside IV attenuates high-glucose-Induced peritoneal fibrosis via modulation of the ENKUR/PI3K/Akt signalling pathway

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Authors

TJTianxin JiangLZLiJie ZhangJLJiahan Liu

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Overview

Randomized trial evaluates Astragaloside IV's effects on peritoneal fibrosis, indicating significant antifibrotic potential.

Key Points

  • The aim is to understand how Astragaloside IV mitigates high-glucose-induced peritoneal fibrosis.
  • Utilized an in vivo uremic rat model and in vitro human peritoneal mesothelial cells
  • Assessed effects of AS-IV on extracellular matrix deposition and collagen accumulation
  • Evaluated expression levels of fibrosis and epithelial-mesenchymal transition markers.
  • AS-IV significantly reduced extracellular matrix deposition and collagen accumulation in vivo.
  • Downregulated α-SMA and collagen IV markers while restoring E-cadherin levels.
  • In vitro, AS-IV suppressed EMT without any observed cytotoxic effects.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6a00217ac8f74e3340f9c505https://doi.org/10.1371/journal.pone.0348762
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