Explores peptide bond formation using anhydride exchange in a chemical synthesis context, suggesting a novel method for advanced peptide synthesis.
Herein, we report a method for peptide bond formation via anhydride exchange‐mediated in situ generation of N‐methylimidazolium cations using trimethylacetic anhydride (Piv 2 O) and catalytic N‐methylimidazole (NMI). It tolerates diverse amino acid side chains (e.g., −OH, indole NH) with no detectable racemization/epimerization even when dipeptides serve as electrophiles. Convergent synthesis of protected Leu‐enkephalin underscores its utility, expanding the toolbox for peptide bond formation.
No takes yet. Share an insight, caveat, or question.
Qi et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: