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This review explores the role of nerve growth factor (NGF) in regulating ovarian physiology and pathology.

May 10, 2026BiomoleculesOpen Access

A Narrative Review of Recent Insights on Nerve Growth Factor Signaling in Physiological and Pathological Ovarian Processes in Mammals

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Narrative review highlights nerve growth factor's role in ovarian health, signaling, and potential biomarkers.

This review explores the role of nerve growth factor (NGF) in regulating ovarian physiology and pathology.
Narrative review synthesizing recent studies on NGF in ovarian tissues.
Focus on NGF signaling pathways and their impact on ovarian function and diseases.
Physiological NGF levels are critical for follicle activation and oocyte maturation.
Both low and high levels of NGF disrupt folliculogenesis and fertility.
Elevated NGF levels are associated with conditions like endometriosis and ovarian cancer.

Aloisi et al. (2026) studied this question.

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