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May 10, 2026SLEEP

0825 Sex-Specific Associations Between Apolipoprotein epsilon-4 Allele Status and Sleep Propensity on the Multiple Sleep Latency Test

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Authors

JCJesse CookJLJessica LoveJBJodi Barnet

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Overview

Randomized trial shows associations between APOEε4 allele and sleep propensity in older adults, suggesting differing effects by sex.

Key Points

  • This study aims to explore the relationship between APOEε4 status, sex, and sleep propensity as measured by the multiple sleep latency test.
  • Utilized a population-based sample of 723 participants from the Wisconsin Sleep Cohort study.
  • Examined 1,028 individual multiple sleep latency tests (MSLTs) with mixed linear models to analyze associations.
  • Included covariates such as age, BMI, antidepressant use, and sleep-related indices in the analysis.
  • Significant sex*APOEε4 interaction observed in fully adjusted models (p=0.012).
  • In men, each additional APOEε4 allele was associated with a mean sleep latency reduction of 1.32 minutes (p<0.001).
  • No significant association found in women (β=0.067, p=0.89).

Cite This Study

Cook et al. (2026) studied this question.

synapsesocial.com/papers/6a0021b7c8f74e3340f9c99bhttps://doi.org/10.1093/sleep/zsag091.0824
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 10217 Among Older Adults, Sex Modulates the APOE Genotype Effects on Sleep and Sleep-Dependent Memory Consolidation2024
  2. 2Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E <b>ɛ</b>4 allele carriers2024 · 23 citations
  3. 31030 APOE Genotype and Sleep Architecture2024
  4. 4An Investigation of Sleep Macro‐ and Microarchitecture by APOE Genotype2026
  5. 50265 Comprehensive Investigation of Sleep Architecture by APOE Genotype: APOE4 Homozygotes have Higher Arousal Thresholds2026