In Vivo Drug-Eluting Smart Scaffold for Diabetic Wounds

efficacy of the patterned scaffold in a diabetic rat model. Wound healing and tissue regeneration were tracked using Swept-Source Optical Coherence Tomography (SS-OCT), histopathology, and molecular analysis (immunohistochemistry and quantitative PCR). We show that the scaffold significantly accelerates wound healing, as evidenced by enhanced cellular differentiation, angiogenesis, and extracellular matrix remodeling. These findings highlight the scaffold's ability to overcome the limitations of current wound care technologies by integrating structural support with sustained drug release. The approach not only improves wound closure and tissue regeneration but also provides a promising, bioinspired solution for targeted diabetic wound management with high potential for clinical translation.