Why the study?
Conventional approaches have proven ineffective for challenging targets like a universal influenza vaccine, but advances in immunology, protein design, and genetic delivery offer new design and delivery possibilities.
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Design
Perspective
Encourages targeted R&D for next-gen influenza vaccines; leaves open clinical validation of efficacy and safety.
Technological advances in immunology, protein design, and genetic delivery have unlocked new possibilities for vaccine concepts and delivery technologies that were previously inaccessible. These next-generation vaccine design efforts are particularly promising in their potential to provide solutions to challenging targets for which conventional approaches have proven ineffective-for example, a universal influenza vaccine. In this perspective, we discuss emerging approaches to vaccine design and engineering based on recent insights into immunology, structural biology, computational biology, and immunoengineering. We anticipate that these cutting-edge, interdisciplinary approaches will lead to breakthrough vaccine concepts for ever-evolving and (re)emerging influenza viruses, with important ramifications for global public health.
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Kanekiyo et al. (2019) studied this question.
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