What question did this study set out to answer?

To review the expanding catalog of immunomodulatory effector molecules produced by helminths and assess their implications for understanding host adaptation and developing therapeutics.

November 1, 2018ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

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Authors

RMRick M. MaizelsNew England Biolabs (United States)HSHermelijn H. SmitsLeiden University Medical Center HMHenry J. McSorleyUniversity of Dundee

Discussion

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Implication

Review outlines mechanisms of host immune modulation by helminth-derived effector molecules, highlighting potential therapeutic applications for immune-mediated diseases.

Key Points

To review the expanding catalog of immunomodulatory effector molecules produced by helminths and assess their implications for understanding host adaptation and developing therapeutics.
Narrative review synthesizing current literature on the molecular mechanisms of helminth-induced immune modulation.
Evaluation of emerging parasite-derived effector molecules and their translational potential in human immune-mediated pathology.
Helminths deploy a diverse repertoire of specialized effector molecules that actively dampen and reprogram host immune responses to ensure parasite persistence.
Identification of these immunomodulatory factors establishes a molecular framework for novel bio-inspired therapies targeting autoimmune and chronic inflammatory conditions.

Cite This Study

Maizels et al. (2018) studied this question.

synapsesocial.com/papers/6a0041c22ff633f36577dd43 https://doi.org/10.1016/j.immuni.2018.10.016

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Implication

Review outlines mechanisms of host immune modulation by helminth-derived effector molecules, highlighting potential therapeutic applications for immune-mediated diseases.

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

Discussion

Member takes

Implication

Key Points

Cite This Study

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

Discussion

Member takes

Implication

Key Points

Cite This Study

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