Why the study?
During the 2009 H1N1 pandemic, data suggested the virus spread might have been interrupted by the autumn rhinovirus epidemic, prompting investigation into viral interference between rhinovirus and influenza A virus.
Does rhinovirus infection prevent subsequent influenza A virus infection in adults and human airway epithelial cultures?
Population
13 707 respiratory specimens from adults (≥21 years) and primary human airway epithelial cultures
Comparison
Observed vs expected co-detections and rhinovirus vs mock infection prior to IAV inoculation
Design
Clinical data analysis and experimental infection study
Authors
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Rhinovirus-IAV co-detection was markedly reduced; hypothesis-generating for mucosal interference and requires prospective trials before any clinical inference.
Does rhinovirus infection prevent subsequent influenza A virus infection in adults and human airway epithelial cultures?
Rhinovirus infection can block subsequent influenza A virus infection through stimulation of antiviral defenses in the airway mucosa.
Wu et al. (2020) studied this question.
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