C–H⋯O non-classical hydrogen bonding in the stereomechanics of organic transformations: theory and recognition

This manuscript describes the role of non-classical hydrogen bonds (NCHBs), specifically C-HO interactions, in modern synthetic organic transformations. Our goal is to point out the seminal examples where C-H···O interactions have been invoked as a key stereocontrolling element and to provide predictive value in recognizing future and/or potential C-H···O interactions in modern transformations.