Why the study?
Does the platelet-lymphocyte ratio predict the degree of coronary collateral circulation in patients with stable angina pectoris and chronic total occlusion?
Does the platelet-lymphocyte ratio predict the degree of coronary collateral circulation in patients with stable angina pectoris and chronic total occlusion?
Higher platelet-lymphocyte ratio is independently associated with poor coronary collateral circulation in patients with stable angina and chronic total occlusion.
PLR should not yet inform collateral assessment in stable angina with CTO; hypothesis-generating and requires prospective validation.
OBJECTIVES: We aimed to investigate the relationship between the platelet-lymphocyte ratio (PLR) and coronary collateral circulation (CCC) in patients with stable angina pectoris (SAP) and chronic total occlusion (CTO). METHODS: A total of 294 patients with both SAP and CTO were classified according to their Rentrop collateral grades as either poor (Rentrop grades/0-1) or good (Rentrop grades/2-3). RESULTS: The PLR values were significantly higher in patients with poor CCC than in those with good CCC (156.8 + 30.7 vs 132.1 + 24.4, P < 0.001). In regression analysis, PLR (unit = 10) [odds ratio 1.48, 95% confidence interval (CI) 1.33 -1.65; P < 0.001] and high-sensitivity C-reactive protein were found to be the independent predictors of poor CCC. In receiver operator characteristic curve analysis, optimal cut-off value of PLR to predict poor CCC was found as 138.1, with 76% sensitivity and 65% specificity. CONCLUSION: PLR may be an important, simple, and cost effective tool predicting the degree of collateralization in patients with SAP and CTO.
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Açar et al. (2013) studied this question.
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