Biochemical study reveals genistein binding interactions in human CaV3.3 channels, highlighting strategies for developing novel T-type calcium channel inhibitors.
3.3 channel as a result of such interaction. Specifically, we proposed that a combination of polar interactions involving the three hydroxyl groups of genistein and an aromatic interaction with the fused rings are the main binding interactions in the complex formation. Our results pave the way for the rational development of improved and novel low-voltage activated T-type calcium channel inhibitors.
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Rangel‐Galván et al. (2021) studied this question.
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