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OBJECTIVE: engages in the PTM of host CRC. DESIGN: cytotoxic T lymphocytes (CTLs) were evaluated in vitro and in vivo. The acetyltransferase activity and downstream target genes of Amuc₂172 were investigated. RESULTS: loci promoted the transcription and secretion of heat-shock protein 70 (HSP70) in cancer cells. High level of HSP70 promoted the immune activity of CTLs in vitro and in vivo. Moreover, bioengineered nanoparticles provided a safe and reliable drug delivery strategy of Amuc₂172 for CRC treatment in an allograft mice model. CONCLUSION: Amuc₂172 reprogrammed tumour microenvironment by inducing HSP70 secretion and promoting CTL-related immune response in the process of tumourigenesis.
Jiang et al. (Wed,) studied this question.
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