What question did this study set out to answer?

To determine whether surface ectoenzymes CD39 and CD73 distinguish regulatory T cells and elucidate how their generation of adenosine drives immune suppression.

May 14, 2007The Journal of Experimental MedicineOpen Access

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

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Authors

SDSilvia DeaglioAzienda Ospedaliera Citta' della Salute e della Scienza di Torino KDKaren M. DwyerThe Royal Melbourne Hospital WGWenda GaoHebei Medical University

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Implication

Preclinical evaluation reveals CD39- and CD73-driven adenosine immunosuppression in regulatory T cells, indicating essential roles in preventing allograft rejection.

Key Points

To determine whether surface ectoenzymes CD39 and CD73 distinguish regulatory T cells and elucidate how their generation of adenosine drives immune suppression.
Assessed the surface co-expression of CD39 and CD73 on CD4(+)/CD25(+)/Foxp3(+) regulatory T cells alongside adenosine A2A receptors on effector T cells.
Evaluated in vitro suppressive capacity and in vivo allograft rejection tolerance using Cd39-null mouse models.
CD39 and CD73 co-expression uniquely marked Foxp3(+) regulatory T cells, driving the pericellular conversion of extracellular nucleotides into immunosuppressive adenosine.
Regulatory T cells deficient in Cd39 showed impaired suppressive properties in vitro and failed to protect against allograft rejection in vivo.

Cite This Study

Deaglio et al. (2007) studied this question.

synapsesocial.com/papers/6a00816c7ac91c5d2a2d6c4d https://doi.org/10.1084/jem.20062512

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Implication

Preclinical evaluation reveals CD39- and CD73-driven adenosine immunosuppression in regulatory T cells, indicating essential roles in preventing allograft rejection.

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

Discussion

Member takes

Implication

Key Points

Cite This Study

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

Discussion

Member takes

Implication

Key Points

Cite This Study

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