What question did this study set out to answer?

To evaluate the efficacy, ongoing pregnancy rates, and adverse events associated with medical abortion using mifepristone followed by buccal misoprostol through 70 days of gestation.

June 7, 2015Obstetrics and GynecologyOpen Access

Mifepristone With Buccal Misoprostol for Medical Abortion

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To evaluate the efficacy, ongoing pregnancy rates, and adverse events associated with medical abortion using mifepristone followed by buccal misoprostol through 70 days of gestation.
Systematic search of PubMed, ClinicalTrials.gov, and reference lists from November 2005 to January 2015 for clinical studies reporting outcomes of mifepristone followed by buccal misoprostol.
Included 20 studies comprising 33,846 women with pregnancies up to 70 days of gestation, stratifying outcomes by gestational age cohorts.
Through 63 days of gestation (approximately 33,000 pregnancies), overall efficacy was 96.7% (95% CI, 96.5–96.8%) with an ongoing pregnancy rate of 0.8% (95% CI, 0.7–0.9%).
Between 64 and 70 days of gestation (n=332), overall efficacy was 93.1% (95% CI, 89.6–95.5%) with a continuing pregnancy rate of 2.9% (95% CI, 1.4–5.7%).
Severe adverse outcomes were rare, with blood transfusion rates between 0.03% and 0.6%, hospitalizations between 0.04% and 0.9%, and non-pregnancy surgical evacuation rates ranging from 1.8% to 4.2%.

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Implication

Systematic review reveals high efficacy and low complication rates for mifepristone plus buccal misoprostol through 63 days of gestation, highlighting its safety for early medical abortion.

Cite This Study

Chen et al. (2015) studied this question.

synapsesocial.com/papers/6a0089514716aad0cc85bbb2 https://doi.org/10.1097/aog.0000000000000897

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Implication

Systematic review reveals high efficacy and low complication rates for mifepristone plus buccal misoprostol through 63 days of gestation, highlighting its safety for early medical abortion.

Mifepristone With Buccal Misoprostol for Medical Abortion

Key Points

Discussion

Implication

Cite This Study

Mifepristone With Buccal Misoprostol for Medical Abortion

Key Points

Discussion

Implication

Cite This Study

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