January 1, 2001Journal of Biological ChemistryOpen Access

Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79

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Population

Human embryonic kidney 293 cells

Design

Preclinical

Authors

MCMei CongPromega (United States)SPStephen J. PerryDefense Systems (United States)FLFang‐Tsyr LinBaylor College of Medicine

Discussion

Member takes

Implication

Preclinical animal data; extends GRK2 regulation mechanisms but leaves open human translation or therapeutic relevance.

Structured PICO

Population

Human embryonic kidney 293 cells

Intervention

Overexpression of AKAP79, AKAP79 mutants, and GRK2 mutagenesis (S685A)

Outcome

Phosphorylation of beta2AR and GRK2-mediated translocation to the membranesurrogate

PKA-mediated phosphorylation of GRK2 on serine 685, facilitated by AKAP79, enhances GRK2 membrane translocation and beta2-adrenergic receptor desensitization.

Cite This Study

Cong et al. (2001) studied this question.

synapsesocial.com/papers/6a009000e92f4a033c854c30 https://doi.org/10.1074/jbc.m009130200

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Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider