Answers are grounded in this paper and cite their sources.
In vitro study demonstrates successful establishment of continuous solid tumor cell lines, indicating distinctive malignant growth characteristics and chromosomal abnormalities.
SUMMARY-A series of 200 human tumors were cultivated in vitro in an attempt to es-tablish cell lines. Lines were established with explant and trypsinization techniques, fr~m 13 tumors including ~arcinomas, sarcomas, mel-anomas, and brain tumors. All these lines in culture for over 1 year, exhibited marked refractility, multilayering, and criss-crossing and were morphologically distinct from nor-mal contact-inhibited human fibroblast or epithelial lines. They also formed colonies on IT!0nolay.e~s of n.ormal cells and grew with a high efficiency In soft agar. Preliminary re-sults!ndica~ed abnormal chromosomal pat-terns In all lines tested, and 8 of 9 cell lines
No takes yet. Share an insight, caveat, or question.
Giard et al. (1973) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: