Why the study?
Appropriate and up-to-date knowledge about early diagnosis and management of cardiac paragangliomas is paramount for optimal outcomes in patients managed by a multidisciplinary team.
This review highlights the importance of Ga-DOTA(0)-Tyr(3)-octreotide PET/CT, genetic testing, and surgical resection in the multidisciplinary management of cardiac paragangliomas.
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May inform diagnostic strategies for rare cardiac paragangliomas; leaves open need for prospective validation.
Ga-DOTA(0)-Tyr(3)-octreotide positron emission tomography/CT, which offers the best cardiac PGL-specific diagnostic accuracy and helps to stage and rule out metastasis, determining the next therapeutic strategies. Patients should also undergo genetic testing, especially for mutations in genes encoding succinate dehydrogenase enzyme subunits that are most commonly present as a genetic cause of these tumours. Curative surgical resection after appropriate α-adrenoceptor and β-adrenoceptor blockade in norepinephrine-secreting tumours is the primary therapeutic strategy. Therefore, appropriate and up-to-date knowledge about early diagnosis and management of cardiac PGLs is paramount for optimal outcomes in patients where a cardiologist is an essential team member of a multidisciplinary team in its management.
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Tella et al. (2020) studied this question.
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