What question did this study set out to answer?

To evaluate the safety of coadministering Tdap and influenza vaccines during pregnancy by comparing acute adverse events and birth outcomes following concomitant versus sequential vaccination.

October 7, 2015Obstetrics and Gynecology

Safety of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis and Influenza Vaccinations in Pregnancy

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Authors

LSLakshmi SukumaranCenters for Disease Control and Prevention NMNatalie McCarthyCenters for Disease Control and Prevention EKElyse O. KharbandaPediatric Cardiology

Discussion

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Implication

Retrospective cohort study finds no increased acute reactions or adverse birth outcomes with simultaneous Tdap and influenza vaccination in pregnancy, indicating coadministration is safe.

Key Points

To evaluate the safety of coadministering Tdap and influenza vaccines during pregnancy by comparing acute adverse events and birth outcomes following concomitant versus sequential vaccination.
Retrospective cohort study of pregnant women aged 14–49 years in the Vaccine Safety Datalink from January 1, 2007, to November 15, 2013 (N=36,844 pregnancies).
Compared medically attended acute reactions (including fever) and adverse birth outcomes (preterm delivery, low birth weight, and small for gestational age) between women receiving concomitant versus sequential vaccination.
Among 36,844 pregnancies receiving both vaccines, 8,464 (23%) received them concomitantly and 28,380 (77%) received them sequentially.
Acute adverse events after vaccination were rare, showing no statistically significant increased risk of fever or any medically attended acute adverse event with concomitant versus sequential administration.
For women vaccinated at 20 weeks of gestation or greater, no differences were observed between concomitant and sequential groups in preterm delivery, low birth weight, or small-for-gestational-age neonates.

Cite This Study

Sukumaran et al. (2015) studied this question.

synapsesocial.com/papers/6a00c3cd2ff633f3657814db https://doi.org/10.1097/aog.0000000000001066

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Implication

Retrospective cohort study finds no increased acute reactions or adverse birth outcomes with simultaneous Tdap and influenza vaccination in pregnancy, indicating coadministration is safe.

Safety of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis and Influenza Vaccinations in Pregnancy

Discussion

Member takes

Implication

Key Points

Cite This Study

Safety of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis and Influenza Vaccinations in Pregnancy

Discussion

Member takes

Implication

Key Points

Cite This Study

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