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Biochemical study demonstrates quinoline drugs promote peroxidative damage and protease inhibition in malaria parasites, suggesting a cytotoxic mechanism tied to free hemin accumulation.
that abounds in parasite digestive vacuole catalyzes peroxidative reactions and inhibition of cysteine proteases. This work suggests a link between the action of quinoline drugs with biochemical processes of peroxidation and inhibition of proteolysis.
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Herraiz et al. (2019) studied this question.
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