Preparation and Preliminary Evaluation of a Novel ⁶⁸ Ga-Labeled Linear Peptide PET Probe Targeting Nectin-4

This is the authors' abstract. We don't add key points for this paper.

OBJECTIVES: Nectin-4 has been successfully used as a target for tumor therapy. Although several bicyclic peptides and antibodies, Nectin-4 positron emission tomography (PET) probes, have been reported for tumor imaging and expression detection, their production costs or pharmacokinetics still need further improvement. This study developed a novel linear peptide PET probe for rapid examination of Nectin-4-related tumors. METHODS: Ga]Ga-NOTA-SP to Nectin-4. Normal BALB/c mice were used to investigate the plasma concentration-time curves. RESULTS: value of 2.483 nM, which was further confirmed by PET-CT imaging. CONCLUSIONS: Ga]Ga-NOTA-SP using a linear peptide as a vector shows favorable pharmacokinetics and specific targeting ability to Nectin-4, enabling rapid tumor mouse model imaging. It would be a promising PET/CT imaging probe for optimizing Nectin-4-related tumor diagnoses and therapy.