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January 1, 2024Organic Chemistry Frontiers

Concise synthesis of pyrrolo[3,4-c]quinolines via a P(NMe₂)₃-catalyzed [4 + 2] annulation followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization

Zhengyang Chen Dan Xiong Nengzhong Wang Yufei Zhang Hui Yao Jinkun Zhang Nianyu Huang Kun Zou

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Abstract

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A P(NMe2)3-catalyzed [4 + 2] annulation of 2-amino-β-nitrostyrenes and β′-acetoxy allenoates followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization has been developed.

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Chen et al. (2024) studied this question.

synapsesocial.com/papers/6a00d4fd10d6befb257777b8 https://doi.org/10.1039/d4qo00169a

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