Single-cell profiling reveals apoptosis gene induction and persistent clonality following alemtuzumab in large granular lymphocyte leukemia, highlighting mechanisms of clonal persistence.
clones, are prominent features of T-LGLL cells. Apoptosis genes are upregulated after alemtuzumab treatment, especially in responders than non-responders; baseline expression levels of apoptosis genes are predictive of hematologic response. Alemtuzumab does not attenuate TCR clonality, and TCR diversity is further skewed after treatment. Inferences made from analysis of single cell data inform understanding of the pathophysiologic mechanisms of clonal expansion and persistence in T-LGLL.
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Gao et al. (2022) studied this question.
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