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This report aims to present a unique case of T-LGLL with severe aplastic anemia and a PNH clone.

July 1, 2026Annals of HematologyOpen Access

A case report of CD4− CD8+ CD56− TCRγδ+ T-large granular lymphocytic leukaemia with severe aplastic anemia and a PNH clone

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Case report describes T-LGLL with aplastic anemia and PNH clone, highlighting diagnostic challenges.

This report aims to present a unique case of T-LGLL with severe aplastic anemia and a PNH clone.
Descriptive case report detailing a patient with CD4− CD8+ CD56− TCRγδ+ T-LGLL.
Assessment of TCRγδ gene rearrangement and associated hematological conditions.
Review of treatment principles and pathophysiological mechanisms for the diseases involved.
Case identified positive TCRγδ gene rearrangement.
Documented T-cell–mediated hematopoietic suppression resulting in severe aplastic anemia.
Identification of a paroxysmal nocturnal hemoglobinuria clone complicating the clinical picture.

Du et al. (2026) studied this question.

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